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Staurosporine targets the Hippo pathway to inhibit cell growth Free
Xueyan Ma 1,† , Peixue Li 1,† , Peihao Chen2,Jinhui Li1, Hongling Huang1, Chao Wang1,Wenjing Li3, Jianping Ding3, Yun Zhao 1,4 ,Fa-Xing Yu5, Xiangbing Qi 2,* ,and Lei Zhang 1,4,*
1 State Key Laboratory of Cell Biology,CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China
2 National Institute of Biological Sciences, Beijing 102206, China
3 National Center for Protein Science Shanghai, State Key Laboratory of Molecular Biology,Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201210, China
4 School of Life Science and Technology,
ShanghaiTech University, Shanghai 201210, China
5 Children’s Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China
†These authors contributed equally to this work. *Correspondence to:Lei Zhang, E-mail: rayzhang@sibcb.ac.cn; Xiangbing Qi, E-mail: qixiangbing@gmail.com
J Mol Cell Biol, Volume 10, Issue 3, June 2018, 267-269,  https://doi.org/10.1093/jmcb/mjy016

Dear Editor,

The Hippo signaling pathway was discovered to control organ size in Drosophila through regulating cell proliferation and apoptosis (Yu et al., 2015). Arising studies over the past two decades have defined the core components and regulation mechanisms of the pathway in both Drosophila and mammals. The core components and fundamental function of the Hippo pathway are highly conserved in mammals. Active Ste20-like kinases 1/2 (MST1/2) phosphorylates adaptor protein Sav family WW domain-containing protein 1 (SAV1) and MOB1A/B, and phosphorylated MOB1A/B could recruit large tumor suppressor 1/2 (LATS1/2) for phosphorylation by MST1/2 at the hydrophobic motif (HM), followed by LATS1/2 autophosphorylation...


Volume 10, Issue 3
June 2018